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Anti-GBM antibodies Article
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Anti-GBM antibodies
Definition
Glomerular basement membrane is a part of the kidneys that helps filter waste and extra fluid from the blood.
Anti-glomerular basement membrane are antibodies against this membrane. They can lead to kidney damage. This article describes the blood test to detect these antibodies.
Alternative Names
GBM antibody test; Antibody to human glomerular basement membrane; Anti-GBM antibodies
Why the Anti-GBM antibodies is Performed
This test is used to diagnose Goodpasture syndrome and certain kidney diseases.
How the Anti-GBM antibodies is Performed
Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
How to Prepare for the Anti-GBM antibodies
No special preparation is necessary.
How the Anti-GBM antibodies Will Feel
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Risks
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Normal Results
No presence of antibodies.
What Abnormal Results Mean
- Goodpasture syndrome
- Acute nephritic syndrome
- Rapidly progressive (crescentic) glomerulonephritis
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